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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736560
Species: Homo sapiens
RGD Object: Gene
Symbol: EPHX1
Name: epoxide hydrolase 1
Acc ID: CHEBI:16482
Term: naphthalene
Definition: An aromatic hydrocarbon comprising two fused benzene rings. It occurs in the essential oils of numerous plant species e.g. magnolia.
Chemical ID: MESH:C031721
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
EPHX1increases expressionEXP 6480464CTDnaphthalene results in increased expression of EPHX1 mRNAPMID:20500019
EPHX1increases metabolic processingISOEphx1 (Mus musculus)6480464CTDEPHX1 protein results in increased metabolism of naphthalenePMID:18363382 PMID:26840748
EPHX1increases response to substanceISOEphx1 (Mus musculus)6480464CTDEPHX1 results in increased susceptibility to naphthalenePMID:26840748
EPHX1multiple interactionsISOEphx1 (Mus musculus)6480464CTD[EPHX1 protein results in increased metabolism of naphthalene] which results in increased chemical synthesis of 1,2-dihydroxy-1,2-dihydronaphthalene; [propionamide analog results in decreased activity of EPHX1 protein] which results in increased glutathionylation of naphthalenePMID:18363382 PMID:26840748
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