GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Nr5a1 | affects expression | ISO | Nr5a1 (Mus musculus) | 6480464 | CTD | Estradiol affects the expression of NR5A1 mRNA | PMID:29092056 | Nr5a1 | decreases response to substance | ISO | NR5A1 (Homo sapiens) | 6480464 | CTD | NR5A1 protein results in decreased susceptibility to Estradiol | PMID:20045459 | Nr5a1 | increases activity | ISO | NR5A1 (Homo sapiens) | 6480464 | CTD | Estradiol results in increased activity of NR5A1 protein | PMID:19549922 | Nr5a1 | multiple interactions | ISO | NR5A1 (Homo sapiens) | 6480464 | CTD | U 0126 inhibits the reaction [Estradiol results in increased activity of NR5A1 protein]; wortmannin inhibits the reaction [Estradiol results in increased activity of NR5A1 protein] | PMID:19549922 | Nr5a1 | multiple interactions | ISO | Nr5a1 (Mus musculus) | 6480464 | CTD | [NR5A1 protein co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased abundance of Estradiol | PMID:21610156 | | ||||||||||||||||||||||
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