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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1309652
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tm4sf1
Name: transmembrane 4 L six family member 1
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tm4sf1decreases expressionISOTM4SF1 (Homo sapiens)6480464CTDEstradiol results in decreased expression of TM4SF1 mRNAPMID:19167446 PMID:24758408 PMID:31646340
Tm4sf1multiple interactionsISOTM4SF1 (Homo sapiens)6480464CTD[Estradiol co-treated with TGFB1 protein] results in decreased expression of TM4SF1 mRNA; EGF protein inhibits the reaction [Estradiol results in decreased expression of TM4SF1 mRNA]; Fulvestrant inhibits the reaction [Estradiol results in decreased expression of TM4SF1 mRNA]PMID:24758408 PMID:30165855 PMID:31646340
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