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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1345848
Species: Homo sapiens
RGD Object: Gene
Symbol: MMP3
Name: matrix metallopeptidase 3
Acc ID: CHEBI:164200
Term: triclosan
Definition: An aromatic ether that is phenol which is substituted at C-5 by a chloro group and at C-2 by a 2,4-dichlorophenoxy group. It is widely used as a preservative and antimicrobial agent in personal care products such as soaps, skin creams, toothpaste and deodorants as well as in household items such as plastic chopping boards, sports equipment and shoes.
Chemical ID: MESH:D014260
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MMP3increases expressionEXP 6480464CTDTriclosan results in increased expression of MMP3 mRNAPMID:26604029
MMP3multiple interactionsEXP 6480464CTDTriclosan inhibits the reaction [Progesterone results in decreased expression of MMP3 mRNA]PMID:26604029
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