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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736485
Species: Mus musculus
RGD Object: Gene
Symbol: Sqstm1
Name: sequestosome 1
Acc ID: CHEBI:16243
Term: quercetin
Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine.
Chemical ID: MESH:D011794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sqstm1affects phosphorylationISOSQSTM1 (Homo sapiens)6480464CTDQuercetin affects the phosphorylation of SQSTM1 proteinPMID:35688186
Sqstm1increases expressionISOSQSTM1 (Homo sapiens)6480464CTDQuercetin results in increased expression of SQSTM1 mRNAPMID:21632981 PMID:26198647
Sqstm1multiple interactionsISOSqstm1 (Rattus norvegicus)6480464CTDQuercetin inhibits the reaction [Cadmium results in increased expression of SQSTM1 protein]PMID:32347499
Sqstm1multiple interactionsISOSQSTM1 (Homo sapiens)6480464CTD3-methyladenine inhibits the reaction [Quercetin results in decreased expression of SQSTM1 protein]; benzyloxycarbonyl-valyl-alanyl-aspartyl-fluoromethane inhibits the reaction [Quercetin results in decreased expression of SQSTM1 protein]; pyrazolanthrone inhibits the reaction [Quercetin results in increased expression of SQSTM1 protein]PMID:25881548 PMID:28251795
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