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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619989
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ido1
Name: indoleamine 2,3-dioxygenase 1
Acc ID: CHEBI:16243
Term: quercetin
Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine.
Chemical ID: MESH:D011794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ido1multiple interactionsEXP 6480464CTDQuercetin inhibits the reaction [Cyclophosphamide results in increased activity of IDO1 protein]; Quercetin inhibits the reaction [Cyclophosphamide results in increased expression of and results in increased activity of IDO1 protein]; Quercetin inhibits the reaction [Cyclophosphamide results in increased expression of IDO1 protein]PMID:34748891 PMID:35906875
Ido1affects bindingISOIDO1 (Homo sapiens)6480464CTDQuercetin binds to IDO1 proteinPMID:35906875
Ido1increases expressionISOIDO1 (Homo sapiens)6480464CTDQuercetin results in increased expression of IDO1 proteinPMID:15221776
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