GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Sqstm1 | affects splicing | EXP | | 6480464 | CTD | Ethanol affects the splicing of SQSTM1 mRNA | PMID:30319688 | Sqstm1 | decreases expression | EXP | | 6480464 | CTD | Ethanol results in decreased expression of SQSTM1 protein | PMID:22459179 PMID:24095927 PMID:36708882 | Sqstm1 | increases degradation | EXP | | 6480464 | CTD | Ethanol results in increased degradation of SQSTM1 protein | PMID:24492484 | Sqstm1 | increases expression | EXP | | 6480464 | CTD | Ethanol results in increased expression of SQSTM1 mRNA; Ethanol results in increased expression of SQSTM1 protein | PMID:25460735 PMID:28419832 PMID:28882574 PMID:34405320 PMID:36535314 | Sqstm1 | multiple interactions | EXP | | 6480464 | CTD | 3-methyladenine inhibits the reaction [Ethanol results in decreased expression of SQSTM1 protein]; [Wortmannin co-treated with Ethanol] results in increased expression of SQSTM1 protein; Dactinomycin inhibits the reaction [Ethanol results in decreased expression of SQSTM1 protein]; dihydromyricetin promotes the reaction [Ethanol results in increased expression of SQSTM1 protein]; Ethanol promotes the reaction [Mirtazapine results in increased expression of SQSTM1 protein]; NR1H4 gene mutant form promotes the reaction [Ethanol results in increased expression of SQSTM1 protein]; pterostilbene inhibits the reaction [Ethanol results in increased expression of SQSTM1 protein]; SESN2 protein promotes the reaction [pterostilbene inhibits the reaction [Ethanol results in increased expression of SQSTM1 protein]]; Sirolimus promotes the reaction [Ethanol results in decreased expression of SQSTM1 protein]; Thymol inhibits the reaction [Ethanol results in increased expression of SQSTM1 protein] | PMID:22459179 PMID:24095927 PMID:25460735 PMID:28419832 PMID:34405320 PMID:35066094 PMID:36535314 PMID:36708882 | Sqstm1 | decreases expression | ISO | Sqstm1 (Rattus norvegicus) | 6480464 | CTD | Ethanol results in decreased expression of SQSTM1 mRNA | PMID:16098508 | Sqstm1 | decreases expression | ISO | SQSTM1 (Homo sapiens) | 6480464 | CTD | Ethanol results in decreased expression of SQSTM1 protein | PMID:29524503 PMID:35595033 | Sqstm1 | increases expression | ISO | SQSTM1 (Homo sapiens) | 6480464 | CTD | Ethanol results in increased expression of SQSTM1 protein | PMID:24582693 PMID:34405320 | Sqstm1 | multiple interactions | ISO | Sqstm1 (Rattus norvegicus) | 6480464 | CTD | 3-methyladenine inhibits the reaction [Ethanol promotes the reaction [Mirtazapine results in increased expression of SQSTM1 protein]]; Ethanol promotes the reaction [Mirtazapine results in increased expression of SQSTM1 protein]; HMGB1 protein affects the reaction [Ethanol promotes the reaction [Mirtazapine results in increased expression of SQSTM1 protein]] | PMID:35066094 | Sqstm1 | multiple interactions | ISO | SQSTM1 (Homo sapiens) | 6480464 | CTD | ADIPOQ protein inhibits the reaction [Ethanol results in increased expression of SQSTM1 protein]; ATG5 protein promotes the reaction [ADIPOQ protein inhibits the reaction [Ethanol results in increased expression of SQSTM1 protein]]; bafilomycin A1 inhibits the reaction [pterostilbene inhibits the reaction [Ethanol results in increased expression of SQSTM1 protein]]; Cycloheximide promotes the reaction [pterostilbene inhibits the reaction [Ethanol results in increased expression of SQSTM1 protein]]; pterostilbene inhibits the reaction [Ethanol results in increased expression of SQSTM1 protein]; SESN2 protein promotes the reaction [pterostilbene inhibits the reaction [Ethanol results in increased expression of SQSTM1 protein]] | PMID:24582693 PMID:34405320 | | ||||||||||||||||||||||
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