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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3731
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sod1
Name: superoxide dismutase 1
Acc ID: CHEBI:15930
Term: atrazine
Definition: A diamino-1,3,5-triazine that is 1,3,5-triazine-2,4-diamine substituted by a chloro group at position 6 while one of hydrogens of each amino group is replaced respectively by an ethyl and a propan-2-yl group.
Chemical ID: MESH:D001280
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sod1decreases activityEXP 6480464CTDAtrazine results in decreased activity of SOD1 proteinPMID:36181348
Sod1decreases expressionEXP 6480464CTDAtrazine results in decreased expression of SOD1 mRNAPMID:23070809
Sod1increases expressionEXP 6480464CTDAtrazine results in increased expression of SOD1 mRNAPMID:23132811
Sod1multiple interactionsEXP 6480464CTDQuercetin inhibits the reaction [Atrazine results in decreased expression of SOD1 mRNA]; Quercetin inhibits the reaction [Atrazine results in increased expression of SOD1 mRNA]PMID:23070809 PMID:23132811
Sod1decreases expressionISOSOD1 (Homo sapiens)6480464CTDAtrazine results in decreased expression of SOD1 mRNAPMID:22378314
Sod1increases expressionISOSod1 (Mus musculus)6480464CTDAtrazine results in increased expression of SOD1 mRNAPMID:36216167
Sod1multiple interactionsISOSod1 (Mus musculus)6480464CTDLycopene inhibits the reaction [Atrazine results in increased expression of SOD1 mRNA]PMID:36216167
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