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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2535
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ednra
Name: endothelin receptor type A
Acc ID: CHEBI:156258
Term: enrasentan
Definition: A member of the class of indanes that is 2,3-dihydro-1H-indene which is substituted by a 1,3-benzodioxol-5-yl group, carboxy group, 2-(2-hydroxyethoxy)-4-methoxyphenyl group and a propoxy group at positions 1S, 2R, 3S and 5, respectively. It is an orally active mixed endothelin A/B receptor antagonist with a 100-fold greater affinity for the endothelin A receptor. The drug was being developed by GSK for the treatment of congestive heart failure and pulmonary hypertension (clinical trials discontinued).
Chemical ID: MESH:C098288
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ednramultiple interactionsISOEDNRA (Homo sapiens)6480464CTDenrasentan binds to and results in decreased activity of EDNRA proteinPMID:16219361
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