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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2165
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Atf3
Name: activating transcription factor 3
Acc ID: CHEBI:15551
Term: prostaglandin E2
Definition: Prostaglandin F2alpha in which the hydroxy group at position 9 has been oxidised to the corresponding ketone. Prostaglandin E2 is the most common and most biologically potent of mammalian prostaglandins.
Chemical ID: MESH:D015232
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Atf3increases expressionISOATF3 (Homo sapiens)6480464CTDDinoprostone results in increased expression of ATF3 proteinPMID:30409902
Atf3multiple interactionsISOATF3 (Homo sapiens)6480464CTDATF3 protein affects the reaction [Dinoprostone results in decreased expression of SIRT1 mRNA]; ATF3 protein affects the reaction [Dinoprostone results in increased expression of CYP19A1 protein]; Dinoprostone promotes the reaction [ATF3 protein binds to SIRT1 promoter]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dinoprostone results in increased expression of ATF3 protein]PMID:30409902
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