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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69032
Species: Homo sapiens
RGD Object: Gene
Symbol: PTGES
Name: prostaglandin E synthase
Acc ID: CHEBI:15379
Term: dioxygen
Definition: An elemental molecule that has formula O2.
Chemical ID: MESH:D010100
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PTGESincreases expressionEXP 6480464CTDOxygen deficiency results in increased expression of PTGES mRNA; Oxygen deficiency results in increased expression of PTGES proteinPMID:20042640
PTGESmultiple interactionsEXP 6480464CTD[Oxygen deficiency results in increased expression of PTGES protein] which results in increased chemical synthesis of Dinoprostone; HIF1A protein promotes the reaction [[Oxygen deficiency results in increased expression of PTGES protein] which results in increased chemical synthesis of Dinoprostone]; PTGES protein promotes the reaction [Oxygen deficiency results in increased expression of HIF1A mRNA]; PTGES protein promotes the reaction [Oxygen deficiency results in increased expression of HIF1A protein]PMID:20042640
PTGESmultiple interactionsISOPtges (Rattus norvegicus)6480464CTD[Oxygen deficiency co-treated with Blood Glucose deficiency co-treated with Particulate Matter] results in increased expression of PTGES mRNAPMID:33729688
PTGESmultiple interactionsISOPtges (Mus musculus)6480464CTD[NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of PTGES mRNAPMID:30529165
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