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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 631379
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp26b1
Name: cytochrome P450, family 26, subfamily b, polypeptide 1
Acc ID: CHEBI:15367
Term: all-trans-retinoic acid
Definition: A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.
Chemical ID: MESH:D014212
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp26b1increases degradationEXP 6480464CTDCYP26B1 protein results in increased degradation of TretinoinPMID:21138835 PMID:27899881
Cyp26b1increases expressionEXP 6480464CTDTretinoin results in increased expression of CYP26B1 mRNAPMID:14592467 PMID:17185629 PMID:17510468 PMID:20488242 PMID:21138835 PMID:22262565
Cyp26b1multiple interactionsEXP 6480464CTD[R 115866 results in decreased activity of CYP26B1 protein] which results in increased abundance of Tretinoin; Lipopolysaccharides inhibits the reaction [Tretinoin results in increased expression of CYP26B1 mRNA]PMID:17185629 PMID:17510468
Cyp26b1affects degradationISOCYP26B1 (Homo sapiens)6480464CTDCYP26B1 protein affects the degradation of TretinoinPMID:16574820
Cyp26b1decreases abundanceISOCYP26B1 (Homo sapiens)6480464CTDCYP26B1 gene SNP results in decreased abundance of TretinoinPMID:29379198
Cyp26b1decreases activityISOCYP26B1 (Homo sapiens)6480464CTDCYP26B1 protein results in decreased activity of TretinoinPMID:20606468
Cyp26b1increases expressionISOCyp26b1 (Mus musculus)6480464CTDTretinoin results in increased expression of CYP26B1 mRNAPMID:16688765
Cyp26b1increases expressionISOCYP26B1 (Homo sapiens)6480464CTDTretinoin results in increased expression of CYP26B1 mRNAPMID:17431108 PMID:17486130 PMID:20606468 PMID:21934132 PMID:23724009 PMID:23830798 PMID:35483669
Cyp26b1increases metabolic processingISOCYP26B1 (Homo sapiens)6480464CTDCYP26B1 protein results in increased metabolism of Tretinoin; CYP26B1 results in increased metabolism of TretinoinPMID:14532297 PMID:17486130
Cyp26b1multiple interactionsISOCyp26b1 (Mus musculus)6480464CTD[mono-(2-ethylhexyl)phthalate co-treated with Tretinoin] results in increased expression of CYP26B1 mRNAPMID:36189433
Cyp26b1multiple interactionsISOCYP26B1 (Homo sapiens)6480464CTD[R 115866 results in decreased activity of CYP26B1 protein] which results in increased activity of Tretinoin; CD2665 inhibits the reaction [Tretinoin results in increased expression of CYP26B1 mRNA]; CYP26B1 protein binds to and results in increased metabolism of Tretinoin; CYP26B1 protein results in increased metabolism of and results in decreased abundance of Tretinoin; Ketoconazole inhibits the reaction [CYP26B1 protein results in increased metabolism of Tretinoin]; Ketoconazole inhibits the reaction [CYP26B1 results in increased metabolism of Tretinoin]; Quinolines analog inhibits the reaction [Tretinoin results in increased expression of CYP26B1 mRNA]; R116010 promotes the reaction [Tretinoin results in increased expression of CYP26B1 mRNA]PMID:14532297 PMID:17486130 PMID:20606468 PMID:21906690 PMID:29379198 PMID:35483669
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