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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2087
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Aldh1a1
Name: aldehyde dehydrogenase 1 family, member A1
Acc ID: CHEBI:15367
Term: all-trans-retinoic acid
Definition: A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.
Chemical ID: MESH:D014212
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Aldh1a1increases chemical synthesisEXP 6480464CTDALDH1A1 protein results in increased chemical synthesis of TretinoinPMID:17497177 PMID:21138835
Aldh1a1multiple interactionsEXP 6480464CTD[DHRS9 protein affects the expression of ALDH1A1 mRNA] which affects the chemical synthesis of Tretinoin; [DHRS9 protein affects the expression of ALDH1A1 protein] which affects the chemical synthesis of TretinoinPMID:21138835
Aldh1a1decreases activityISOALDH1A1 (Homo sapiens)6480464CTDTretinoin results in decreased activity of ALDH1A1 proteinPMID:16614850
Aldh1a1decreases expressionISOALDH1A1 (Homo sapiens)6480464CTDTretinoin results in decreased expression of ALDH1A1 proteinPMID:16614850
Aldh1a1increases chemical synthesisISOAldh1a1 (Mus musculus)6480464CTDALDH1A1 protein results in increased chemical synthesis of TretinoinPMID:16207763 PMID:18831967
Aldh1a1increases expressionISOAldh1a1 (Mus musculus)6480464CTDTretinoin results in increased expression of ALDH1A1 mRNAPMID:12834868
Aldh1a1multiple interactionsISOAldh1a1 (Mus musculus)6480464CTD[DHRS3 gene mutant form results in increased abundance of Tretinoin] which results in decreased expression of ALDH1A1 mRNA; [mono-(2-ethylhexyl)phthalate co-treated with Tretinoin] results in decreased expression of ALDH1A1 mRNAPMID:24005908 PMID:36189433
Aldh1a1multiple interactionsISOALDH1A1 (Homo sapiens)6480464CTD[ALDH1A1 protein co-treated with SDR16C5 protein] results in increased chemical synthesis of Tretinoin; Tretinoin results in decreased expression of and results in decreased activity of ALDH1A1 proteinPMID:15470086 PMID:27793605
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