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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70912
Species: Rattus norvegicus
RGD Object: Gene
Symbol: P2ry14
Name: purinergic receptor P2Y14
Acc ID: CHEBI:135938
Term: lasofoxifene
Definition: A member of the class of tetralins that is 5,6,7,8-tetrahydronaphthalen-2-ol in which the hydrogens at positions 5 and 6 are replaced by 4-[2-(pyrrolidin-1-yl)ethoxy]phenyl and phenyl groups, respectively (the 5R,6S-stereoisomer). It is a selective estrogen receptor modulator indicated for the prevention and treatment of osteoporosis in post-menopausal women.
Chemical ID: MESH:C111332
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
P2ry14multiple interactionsISOP2ry14 (Mus musculus)6480464CTDLasofoxifene inhibits the reaction [Estradiol results in increased expression of P2RY14 mRNA]PMID:18367319
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