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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69328
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdkn1a
Name: cyclin-dependent kinase inhibitor 1A
Acc ID: CHEBI:10782
Term: (S)-(-)-perillyl alcohol
Definition: A perillyl alcohol in which the chiral centre has S configuration.
Chemical ID: MESH:C032208
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdkn1aincreases expressionISOCDKN1A (Homo sapiens)6480464CTDperillyl alcohol results in increased expression of CDKN1A proteinPMID:17138864
Cdkn1aincreases response to substanceISOCDKN1A (Homo sapiens)6480464CTDCDKN1A protein results in increased susceptibility to perillyl alcoholPMID:17138864
Cdkn1amultiple interactionsISOCDKN1A (Homo sapiens)6480464CTDperillyl alcohol promotes the reaction [CDKN1A protein binds to and results in decreased activity of CDK2 protein]PMID:17138864
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