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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2544
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Egr1
Name: early growth response 1
Acc ID: CHEBI:10022
Term: deoxynivalenol
Definition: A trichothecene mycotoxin produced by Fusarium to which wheat, barley, maize (corn) and their products are susceptible to contamination.
Chemical ID: MESH:C007262
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Egr1increases expressionISOEGR1 (Homo sapiens)6480464CTD[deoxynivalenol results in increased expression of EGR1 protein] which results in increased expression of CXCL8 protein; deoxynivalenol results in increased expression of EGR1 mRNA; deoxynivalenol results in increased expression of EGR1 proteinPMID:17707346 PMID:18485432 PMID:19360757 PMID:30286430 PMID:33890134
Egr1multiple interactionsISOEGR1 (Homo sapiens)6480464CTDATF3 protein affects the reaction [deoxynivalenol results in increased expression of EGR1 protein]; deoxynivalenol results in increased expression of and results in increased phosphorylation of EGR1 protein; EGR1 protein affects the reaction [deoxynivalenol results in increased expression of CDKN1A protein]; EGR1 protein promotes the reaction [deoxynivalenol results in increased expression of PPARG mRNA]PMID:18485432 PMID:19360757 PMID:30286430
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