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GENE - TERM ANNOTATION REPORT

RGD ID: 9034222
Species: Chinchilla lanigera
RGD Object: Gene
Symbol: Esr1
Name: estrogen receptor 1
Acc ID: DOID:9004914
Term: Postmenopausal Osteoporosis
Definition: Metabolic disorder associated with fractures of the femoral neck, vertebrae, and distal forearm. It occurs commonly in women within 15-20 years after menopause, and is caused by factors associated with menopause including estrogen deficiency.
Definition Source(s): MESH:D015663
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr1susceptibilityISOESR1 (Homo sapiens)9068941RGDDNA:SNPs, haplotype:intron: (rs2234693, rs9340799) (human)PMID:16972020 REF_RGD_ID:10045838
Esr1treatmentISOESR1 (Homo sapiens)9068941RGDDNA:SNP:intron:IVS1T>C (human)PMID:16604479 REF_RGD_ID:8158082
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