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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737547
Species: Mus musculus
RGD Object: Gene
Symbol: Cbr1
Name: carbonyl reductase 1
Acc ID: CHEBI:16243
Term: quercetin
Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine.
Chemical ID: MESH:D011794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cbr1multiple interactionsISOCBR1 (Homo sapiens)6480464CTD[Quercetin co-treated with NADP] binds to CBR1 protein; Quercetin binds to and results in decreased activity of CBR1 protein; Quercetin inhibits the reaction [CBR1 protein results in increased metabolism of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone]; Quercetin inhibits the reaction [CBR1 protein results in increased reduction of 2,3-hexanedione]PMID:11306090 PMID:25526675 PMID:25541467
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