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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737414
Species: Mus musculus
RGD Object: Gene
Symbol: Cdh1
Name: cadherin 1
Acc ID: CHEBI:9168
Term: sirolimus
Definition: A macrolide lactam isolated from Streptomyces hygroscopicus consisting of a 29-membered ring containing 4 trans double bonds, three of which are conjugated. It is an antibiotic, immunosupressive and antineoplastic agent.
Chemical ID: MESH:D020123
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdh1increases expressionISOCDH1 (Homo sapiens)6480464CTDSirolimus results in increased expression of CDH1 proteinPMID:28888487
Cdh1multiple interactionsISOCdh1 (Rattus norvegicus)6480464CTDNFE2L2 protein promotes the reaction [Sirolimus inhibits the reaction [Paraquat results in decreased expression of CDH1 protein]]; Sirolimus inhibits the reaction [Paraquat results in decreased expression of CDH1 mRNA]; Sirolimus inhibits the reaction [Paraquat results in decreased expression of CDH1 protein]; Sirolimus promotes the reaction [Dibutyl Phthalate results in decreased expression of CDH1 mRNA]; Sirolimus promotes the reaction [Dibutyl Phthalate results in decreased expression of CDH1 protein]PMID:28624451 PMID:30053495
Cdh1multiple interactionsISOCDH1 (Homo sapiens)6480464CTDSirolimus inhibits the reaction [sodium arsenite results in decreased expression of CDH1 protein]PMID:28888487
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