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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737309
Species: Homo sapiens
RGD Object: Gene
Symbol: PPARA
Name: peroxisome proliferator activated receptor alpha
Acc ID: CHEBI:64294
Term: 7-ketocholesterol
Definition: A cholestanoid that consists of cholesterol bearing an oxo substituent at position 7.
Chemical ID: MESH:C003001
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PPARAdecreases expressionISOPpara (Mus musculus)6480464CTD7-ketocholesterol results in decreased expression of PPARA mRNAPMID:29065513
PPARAmultiple interactionsISOPpara (Mus musculus)6480464CTDalpha-Tocopherol inhibits the reaction [7-ketocholesterol results in decreased expression of PPARA mRNA]; argan oil inhibits the reaction [7-ketocholesterol results in decreased expression of PPARA mRNA]PMID:29065513
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