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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736560
Species: Homo sapiens
RGD Object: Gene
Symbol: EPHX1
Name: epoxide hydrolase 1
Acc ID: CHEBI:17747
Term: bis(2-ethylhexyl) phthalate
Definition: A phthalate ester that is the bis(2-ethylhexyl) ester of benzene-1,2-dicarboxylic acid.
Chemical ID: MESH:D004051
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
EPHX1decreases activityISOEphx1 (Rattus norvegicus)6480464CTDDiethylhexyl Phthalate results in decreased activity of EPHX1 proteinPMID:10528994
EPHX1increases activityISOEphx1 (Mus musculus)6480464CTDDiethylhexyl Phthalate results in increased activity of EPHX1 proteinPMID:3621371
EPHX1increases expressionISOEphx1 (Mus musculus)6480464CTDDiethylhexyl Phthalate results in increased expression of EPHX1 mRNA; Diethylhexyl Phthalate results in increased expression of EPHX1 proteinPMID:19850644 PMID:3318844
EPHX1increases expressionISOEphx1 (Rattus norvegicus)6480464CTDDiethylhexyl Phthalate results in increased expression of EPHX1 mRNAPMID:35970509
EPHX1multiple interactionsISOEphx1 (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of EPHX1 mRNAPMID:28433925
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