GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | ESR1 | affects binding | EXP | | 6480464 | CTD | butylparaben binds to ESR1 protein; butylparaben metabolite binds to ESR1 protein | PMID:11193391 PMID:19063592 PMID:20074635 PMID:29945225 | ESR1 | decreases activity | EXP | | 6480464 | CTD | butylparaben results in decreased activity of ESR1 protein | PMID:25012808 | ESR1 | decreases expression | EXP | | 6480464 | CTD | butylparaben results in decreased expression of ESR1 mRNA | PMID:23524099 | ESR1 | increases activity | EXP | | 6480464 | CTD | butylparaben results in increased activity of ESR1 protein | PMID:22562034 | ESR1 | increases expression | EXP | | 6480464 | CTD | butylparaben results in increased expression of ESR1 mRNA; butylparaben results in increased expression of ESR1 protein | PMID:25128701 | ESR1 | multiple interactions | EXP | | 6480464 | CTD | [butylparaben co-treated with NRG1 protein] promotes the reaction [ESR1 protein binds to MYC enhancer]; butylparaben binds to and results in increased activity of ESR1 protein; Fulvestrant inhibits the reaction [butylparaben results in increased activity of ESR1 protein] | PMID:20362049 PMID:20435135 PMID:22562034 PMID:23567241 PMID:25012808 PMID:26502914 | ESR1 | affects binding | ISO | Esr1 (Rattus norvegicus) | 6480464 | CTD | butylparaben binds to ESR1 protein | PMID:15204698 PMID:20132880 | ESR1 | decreases expression | ISO | Esr1 (Rattus norvegicus) | 6480464 | CTD | butylparaben results in decreased expression of ESR1 mRNA; butylparaben results in decreased expression of ESR1 protein | PMID:19654335 PMID:27444704 | ESR1 | decreases methylation | ISO | Esr1 (Rattus norvegicus) | 6480464 | CTD | butylparaben results in decreased methylation of ESR1 promoter | PMID:26888303 | ESR1 | increases expression | ISO | Esr1 (Rattus norvegicus) | 6480464 | CTD | butylparaben results in increased expression of ESR1 mRNA; butylparaben results in increased expression of ESR1 protein | PMID:26888303 | ESR1 | multiple interactions | ISO | Esr1 (Rattus norvegicus) | 6480464 | CTD | [Plasticizers co-treated with Fungicides, Industrial co-treated with Linuron co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with Dichlorodiphenyl Dichloroethylene co-treated with butylparaben co-treated with Acetaminophen] results in decreased expression of ESR1 mRNA; butylparaben inhibits the reaction [Estradiol binds to ESR1 protein]; Fulvestrant inhibits the reaction [butylparaben results in decreased expression of ESR1 mRNA]; Fulvestrant inhibits the reaction [butylparaben results in decreased expression of ESR1 protein] | PMID:15204698 PMID:19654335 PMID:34383603 | | ||||||||||||||||||||||
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