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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736559
Species: Homo sapiens
RGD Object: Gene
Symbol: ESR1
Name: estrogen receptor 1
Acc ID: CHEBI:7627
Term: norethisterone
Definition: A 17beta-hydroxy steroid that is testosterone in which the hydrogen at position 17 is replaced by an ethynyl group and in which the methyl group attached to position 10 is replaced by hydrogen.
Chemical ID: MESH:D009640
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ESR1multiple interactionsEXP 6480464CTDESR1 protein affects the reaction [Norethindrone results in increased expression of GREB1 mRNA]; ESR1 protein affects the reaction [Norethindrone results in increased expression of SGK1 mRNA]; Norethindrone binds to and results in increased activity of ESR1 proteinPMID:25012808 PMID:25752796 PMID:33049310 PMID:33405908
ESR1increases activityISOEsr1 (Rattus norvegicus)6480464CTDNorethindrone results in increased activity of ESR1 proteinPMID:11750080 PMID:12504345
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