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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736559
Species: Homo sapiens
RGD Object: Gene
Symbol: ESR1
Name: estrogen receptor 1
Acc ID: CHEBI:73275
Term: ospemifene
Definition: An organochlorine compound that is a selective estrogen receptor modulator; used for treatment of dyspareunia.
Chemical ID: MESH:C119141
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ESR1decreases expressionEXP 6480464CTDOspemifene results in decreased expression of ESR1 mRNA; Ospemifene results in decreased expression of ESR1 proteinPMID:27163517
ESR1multiple interactionsEXP 6480464CTDOspemifene inhibits the reaction [Estradiol results in increased expression of ESR1 protein]PMID:27163517
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