Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736559
Species: Homo sapiens
RGD Object: Gene
Symbol: ESR1
Name: estrogen receptor 1
Acc ID: CHEBI:6954
Term: Mitotane
Definition: null
Chemical ID: MESH:D008939
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ESR1affects bindingEXP 6480464CTDMitotane binds to ESR1 proteinPMID:14579009
ESR1increases activityEXP 6480464CTDMitotane results in increased activity of ESR1 proteinPMID:26139245
ESR1multiple interactionsEXP 6480464CTDESR1 protein promotes the reaction [Mitotane results in increased expression of SERPINA6 protein]; ESR1 protein promotes the reaction [Mitotane results in increased expression of SHBG protein]; Mitotane binds to and results in increased activity of ESR1 protein; Mitotane inhibits the reaction [Estradiol binds to ESR1 protein]PMID:14579009 PMID:16551731 PMID:33049310 PMID:8930550
ESR1increases activityISOEsr1 (Rattus norvegicus)6480464CTDMitotane results in increased activity of ESR1 proteinPMID:28531659
ESR1multiple interactionsISOEsr1 (Rattus norvegicus)6480464CTDMitotane inhibits the reaction [Estradiol binds to ESR1 protein]; Mitotane inhibits the reaction [Estradiol results in increased activity of ESR1 protein]PMID:10580743 PMID:28531659
Go Back to source page   Continue to Ontology report