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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736559
Species: Homo sapiens
RGD Object: Gene
Symbol: ESR1
Name: estrogen receptor 1
Acc ID: CHEBI:4791
Term: endosulfan
Definition: A cyclic sulfite ester that is 1,5,5a,6,9,9a-hexahydro-6,9-methano-2,4,3-benzodioxathiepine 3-oxide substituted by chloro groups at positions 6, 7, 8, 9, 10 and 10.
Chemical ID: MESH:D004726
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ESR1affects bindingEXP 6480464CTDEndosulfan binds to ESR1 proteinPMID:14579009 PMID:19913605
ESR1decreases expressionEXP 6480464CTDEndosulfan results in decreased expression of ESR1 mRNAPMID:15261991 PMID:28673560
ESR1increases activityEXP 6480464CTDEndosulfan results in increased activity of ESR1 proteinPMID:15064155 PMID:26139245
ESR1multiple interactionsEXP 6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Endosulfan affects the activity of ESR1 protein] promotes the reaction [LIF protein results in increased activity of STAT3 protein]]; [Endosulfan affects the activity of ESR1 protein] promotes the reaction [LIF protein results in increased activity of STAT3 protein]; Endosulfan binds to and results in increased activity of ESR1 protein; Endosulfan inhibits the reaction [Estradiol binds to ESR1 protein]; Endosulfan promotes the reaction [ESR1 protein results in increased abundance of Glucose]; Endosulfan promotes the reaction [ESR1 protein results in increased expression of G6PC1 mRNA]; ESR1 mRNA promotes the reaction [Endosulfan results in increased expression of CYP2B6 mRNA]; ESR1 mRNA promotes the reaction [Endosulfan results in increased expression of CYP3A4 mRNA]; ESR1 protein inhibits the reaction [Endosulfan results in increased expression of CCN5 mRNA]; ESR1 protein inhibits the reaction [Endosulfan results in increased expression of GREB1 mRNA]; ESR1 protein inhibits the reaction [Endosulfan results in increased expression of TFF1 mRNA]; Tamoxifen inhibits the reaction [[Endosulfan affects the activity of ESR1 protein] promotes the reaction [LIF protein results in increased activity of STAT3 protein]]PMID:10397250 PMID:10774817 PMID:14579009 PMID:14975756 PMID:16626760 PMID:23384675 PMID:28673560 PMID:31520823 PMID:33049310
ESR1affects bindingISOEsr1 (Mus musculus)6480464CTDEndosulfan binds to ESR1 proteinPMID:19913605
ESR1affects methylationISOEsr1 (Rattus norvegicus)6480464CTDEndosulfan affects the methylation of ESR1 promoter alternative formPMID:28559116
ESR1decreases expressionISOEsr1 (Mus musculus)6480464CTDEndosulfan results in decreased expression of ESR1 proteinPMID:21278053
ESR1decreases expressionISOEsr1 (Rattus norvegicus)6480464CTDEndosulfan results in decreased expression of ESR1 mRNA; Endosulfan results in decreased expression of ESR1 proteinPMID:18790044 PMID:29391264
ESR1decreases methylationISOEsr1 (Rattus norvegicus)6480464CTDEndosulfan results in decreased methylation of ESR1 promoterPMID:28559116
ESR1increases activityISOEsr1 (Rattus norvegicus)6480464CTDEndosulfan results in increased activity of ESR1 proteinPMID:17174995 PMID:9860891
ESR1increases expressionISOEsr1 (Rattus norvegicus)6480464CTDEndosulfan results in increased expression of ESR1 mRNA; Endosulfan results in increased expression of ESR1 mRNA alternative form; Endosulfan results in increased expression of ESR1 proteinPMID:22198180 PMID:25486513 PMID:28559116 PMID:28935589 PMID:31550491
ESR1multiple interactionsISOEsr1 (Mus musculus)6480464CTDEndosulfan inhibits the reaction [Estradiol binds to ESR1 protein]PMID:21278053
ESR1multiple interactionsISOEsr1 (Rattus norvegicus)6480464CTD[o,p'-DDT co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Methoxychlor co-treated with Endosulfan co-treated with DDT] results in increased activity of ESR1 proteinPMID:9860891
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