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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736559
Species: Homo sapiens
RGD Object: Gene
Symbol: ESR1
Name: estrogen receptor 1
Acc ID: CHEBI:42309
Term: equilin
Definition: A 17-oxo steroid that has formula C18H20O2.
Chemical ID: MESH:D004857
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ESR1affects bindingEXP 6480464CTDEquilin binds to ESR1 proteinPMID:21138273
ESR1increases activityEXP 6480464CTDEquilin results in increased activity of ESR1 proteinPMID:22562034
ESR1multiple interactionsEXP 6480464CTDEquilin binds to and results in increased activity of ESR1 protein; Fulvestrant inhibits the reaction [Equilin results in increased activity of ESR1 protein]PMID:22562034 PMID:33049310
ESR1increases activityISOEsr1 (Rattus norvegicus)6480464CTDEquilin results in increased activity of ESR1 proteinPMID:11750080 PMID:12504345
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