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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736559
Species: Homo sapiens
RGD Object: Gene
Symbol: ESR1
Name: estrogen receptor 1
Acc ID: CHEBI:39421
Term: perfluorooctane-1-sulfonic acid
Definition: A perfluoroalkanesulfonic acid that is octane-1-sulfonic acid in which all seventeen of the hydrogens that are attached to carbons hvae been replaced by fluorines.
Chemical ID: MESH:C076994
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ESR1affects bindingEXP 6480464CTDperfluorooctane sulfonic acid binds to [ESR1 protein binds to Estradiol]PMID:33111528
ESR1increases expressionEXP 6480464CTDperfluorooctane sulfonic acid results in increased expression of ESR1 mRNAPMID:22269386
ESR1multiple interactionsEXP 6480464CTDESR1 protein affects the reaction [[Hydrocarbons, Chlorinated co-treated with perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Hexachlorobenzene] results in increased secretion of IGF1 protein]; perfluorooctane sulfonic acid binds to and results in increased activity of ESR1 proteinPMID:21163906 PMID:31923581
ESR1decreases expressionISOEsr1 (Mus musculus)6480464CTDperfluorooctane sulfonic acid results in decreased expression of ESR1 proteinPMID:34303733
ESR1multiple interactionsISOEsr1 (Mus musculus)6480464CTD[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of ESR1 mRNA; [perfluorooctane sulfonic acid co-treated with Inulin] results in decreased expression of ESR1 mRNAPMID:36331819
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