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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736559
Species: Homo sapiens
RGD Object: Gene
Symbol: ESR1
Name: estrogen receptor 1
Acc ID: CHEBI:34887
Term: nickel dichloride
Definition: A compound of nickel and chloride in which the ratio of nickel (in the +2 oxidation state) to chloride is 1:2.
Chemical ID: MESH:C022838
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ESR1affects response to substanceEXP 6480464CTDESR1 protein affects the susceptibility to nickel chloridePMID:12746304
ESR1decreases expressionEXP 6480464CTDnickel chloride results in decreased expression of ESR1 mRNA; nickel chloride results in decreased expression of ESR1 proteinPMID:12746304
ESR1multiple interactionsEXP 6480464CTDnickel chloride binds to and results in increased activity of ESR1 protein; nickel chloride inhibits the reaction [Estradiol binds to ESR1 protein]PMID:12746304
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