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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736559
Species: Homo sapiens
RGD Object: Gene
Symbol: ESR1
Name: estrogen receptor 1
Acc ID: CHEBI:34696
Term: dieldrin
Definition: An organochlorine compound resulting from the epoxidation of the double bond of aldrin. It is the active metabolite of the proinsecticde aldrin.
Chemical ID: MESH:D004026
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ESR1affects bindingEXP 6480464CTDDieldrin binds to ESR1 proteinPMID:14579009
ESR1increases activityEXP 6480464CTDDieldrin results in increased activity of ESR1 proteinPMID:15064155 PMID:26022396
ESR1increases expressionEXP 6480464CTDDieldrin results in increased expression of ESR1 mRNAPMID:11922773 PMID:21295777
ESR1multiple interactionsEXP 6480464CTD[DDT analog co-treated with Hexachlorocyclohexane analog co-treated with Chlorobenzenes co-treated with Mirex co-treated with Polychlorinated Biphenyls co-treated with Chlordan co-treated with Toxaphene co-treated with Aldrin co-treated with Dieldrin] results in increased expression of ESR1 mRNA; [Dieldrin co-treated with alachlor] inhibits the reaction [Estradiol binds to ESR1 protein]; [Dieldrin co-treated with Chlordan] inhibits the reaction [Estradiol binds to ESR1 protein]; [o,p'-DDT co-treated with Methoxychlor co-treated with Dieldrin] results in increased expression of ESR1 mRNA; [Toxaphene co-treated with Dieldrin co-treated with Chlordan] inhibits the reaction [Estradiol binds to ESR1 protein]; Dieldrin binds to and results in increased activity of ESR1 protein; Dieldrin inhibits the reaction [Estradiol binds to ESR1 protein]; Dieldrin inhibits the reaction [Estradiol results in decreased expression of ESR1 mRNA]PMID:10774817 PMID:11922773 PMID:14579009 PMID:15261991 PMID:16626760 PMID:21295777 PMID:9168004
ESR1decreases expressionISOEsr1 (Mus musculus)6480464CTDDieldrin results in decreased expression of ESR1 proteinPMID:21278053
ESR1increases activityISOEsr1 (Rattus norvegicus)6480464CTDDieldrin results in increased activity of ESR1 proteinPMID:17174995
ESR1multiple interactionsISOEsr1 (Mus musculus)6480464CTDDieldrin inhibits the reaction [Estradiol binds to ESR1 protein]PMID:21278053
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