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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736559
Species: Homo sapiens
RGD Object: Gene
Symbol: ESR1
Name: estrogen receptor 1
Acc ID: CHEBI:34631
Term: chlorpyrifos
Definition: An organic thiophosphate that is O,O-diethyl hydrogen phosphorothioate in which the hydrogen of the hydroxy group has been replaced by a 3,5,6-trichloropyridin-2-yl group.
Chemical ID: MESH:D004390
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ESR1decreases activityEXP 6480464CTDChlorpyrifos results in decreased activity of ESR1 proteinPMID:22562034
ESR1decreases expressionEXP 6480464CTDChlorpyrifos results in decreased expression of ESR1 mRNAPMID:32171938
ESR1increases activityEXP 6480464CTDChlorpyrifos results in increased activity of ESR1 proteinPMID:15064155 PMID:26812056 PMID:28728110 PMID:32171938
ESR1increases expressionEXP 6480464CTDChlorpyrifos results in increased expression of ESR1 mRNAPMID:35457321
ESR1multiple interactionsEXP 6480464CTD[APOE gene polymorphism affects the susceptibility to Chlorpyrifos] which affects the expression of ESR1 mRNA; [Chlorpyrifos co-treated with fenarimol co-treated with Estradiol] results in increased activity of ESR1 protein; [fludioxonil co-treated with N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide co-treated with Chlorpyrifos] results in increased activity of ESR1 protein; afimoxifene inhibits the reaction [[Chlorpyrifos co-treated with Estradiol] results in increased activity of ESR1 protein]; Chlorpyrifos promotes the reaction [Estradiol results in increased activity of ESR1 protein]; Tamoxifen inhibits the reaction [Chlorpyrifos results in increased activity of ESR1 protein]PMID:26812056 PMID:31472362 PMID:32171938
ESR1affects expressionISOEsr1 (Rattus norvegicus)6480464CTDChlorpyrifos affects the expression of ESR1 mRNAPMID:34858468
ESR1decreases expressionISOEsr1 (Mus musculus)6480464CTDChlorpyrifos results in decreased expression of ESR1 proteinPMID:34571837 PMID:36769379
ESR1decreases expressionISOEsr1 (Rattus norvegicus)6480464CTDChlorpyrifos results in decreased expression of ESR1 protein modified formPMID:26518068
ESR1increases expressionISOEsr1 (Mus musculus)6480464CTDChlorpyrifos results in increased expression of ESR1 mRNAPMID:34571837
ESR1multiple interactionsISOEsr1 (Mus musculus)6480464CTD[Chlorpyrifos co-treated with Triiodothyronine] results in increased expression of ESR1 mRNAPMID:34571837
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