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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736559
Species: Homo sapiens
RGD Object: Gene
Symbol: ESR1
Name: estrogen receptor 1
Acc ID: CHEBI:34440
Term: 4-nonylphenol
Definition: A member of the class of phenols that is phenol which is para-substituted with a nonyl group.
Chemical ID: MESH:C041594
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ESR1affects bindingEXP 6480464CTD4-nonylphenol binds to ESR1 proteinPMID:11518614 PMID:12598185 PMID:19720131 PMID:19913605 PMID:20353888
ESR1decreases expressionEXP 6480464CTD4-nonylphenol results in decreased expression of ESR1 mRNAPMID:16393665
ESR1increases activityEXP 6480464CTD4-nonylphenol results in increased activity of ESR1 protein; 4-nonylphenol results in increased activity of ESR1 protein mutant formPMID:17141713 PMID:25012808 PMID:28728110 PMID:29066353
ESR1multiple interactionsEXP 6480464CTD4-nonylphenol binds to and results in increased activity of ESR1 protein; 4-nonylphenol inhibits the reaction [Estradiol binds to ESR1 protein]; [4-nonylphenol co-treated with ESR1 protein] results in increased expression of LTF mRNA; ESR1 protein inhibits the reaction [4-nonylphenol results in increased expression of CCN5 mRNA]PMID:11530281 PMID:12127041 PMID:19720131 PMID:21783566 PMID:23384675 PMID:27633901 PMID:29162470
ESR1affects localizationISOEsr1 (Mus musculus)6480464CTD4-nonylphenol affects the localization of ESR1 proteinPMID:20950447
ESR1decreases expressionISOEsr1 (Mus musculus)6480464CTD4-nonylphenol analog results in decreased expression of ESR1 mRNA; 4-nonylphenol analog results in decreased expression of ESR1 proteinPMID:27086933
ESR1decreases expressionISOEsr1 (Rattus norvegicus)6480464CTD4-nonylphenol results in decreased expression of ESR1 mRNA; 4-nonylphenol results in decreased expression of ESR1 proteinPMID:24388992
ESR1increases activityISOEsr1 (Rattus norvegicus)6480464CTD4-nonylphenol results in increased activity of ESR1 proteinPMID:17174995
ESR1multiple interactionsISOEsr1 (Mus musculus)6480464CTD4-nonylphenol inhibits the reaction [Estradiol results in increased expression of ESR1 mRNA]PMID:22056370
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