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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736559
Species: Homo sapiens
RGD Object: Gene
Symbol: ESR1
Name: estrogen receptor 1
Acc ID: CHEBI:28499
Term: kaempferol
Definition: A tetrahydroxyflavone in which the four hydroxy groups are located at positions 3, 5, 7 and 4'. Acting as an antioxidant by reducing oxidative stress, it is currently under consideration as a possible cancer treatment.
Chemical ID: MESH:C006552
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ESR1affects bindingEXP 6480464CTDkaempferol binds to ESR1 proteinPMID:14579009 PMID:14706564 PMID:19913605
ESR1increases activityEXP 6480464CTDkaempferol results in increased activity of ESR1 proteinPMID:16118406
ESR1increases expressionEXP 6480464CTDkaempferol results in increased expression of ESR1 mRNAPMID:15182386
ESR1multiple interactionsEXP 6480464CTDESR1 protein inhibits the reaction [kaempferol results in increased expression of CCN5 mRNA]; ESR1 protein inhibits the reaction [kaempferol results in increased expression of PGR mRNA]; ESR1 protein inhibits the reaction [kaempferol results in increased expression of TFF1 mRNA]; Estradiol affects the reaction [kaempferol results in increased activity of ESR1 protein]; kaempferol binds to and results in increased activity of ESR1 protein; kaempferol inhibits the reaction [Estradiol binds to ESR1 protein]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to CYP1A1 enhancer]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to CYP1B1 enhancer]]; kaempferol promotes the reaction [ESR1 protein binds to GREB1 enhancer]; kaempferol results in increased expression of and results in increased localization of ESR1 proteinPMID:14579009 PMID:15182386 PMID:16118406 PMID:20846786 PMID:23384675 PMID:29162470 PMID:33049310 PMID:9751507
ESR1affects bindingISOEsr1 (Mus musculus)6480464CTDkaempferol binds to ESR1 proteinPMID:19913605
ESR1affects bindingISOEsr1 (Rattus norvegicus)6480464CTDkaempferol binds to ESR1 proteinPMID:19913605
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