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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736559
Species: Homo sapiens
RGD Object: Gene
Symbol: ESR1
Name: estrogen receptor 1
Acc ID: CHEBI:18088
Term: formononetin
Definition: A member of the class of 7-hydroxyisoflavones that is 7-hydroxyisoflavone substituted by a methoxy group at position 4'.
Chemical ID: MESH:C007768
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ESR1affects bindingEXP 6480464CTDformononetin binds to ESR1 proteinPMID:16773531
ESR1multiple interactionsEXP 6480464CTDformononetin binds to and results in increased activity of ESR1 proteinPMID:16076101 PMID:9751507
ESR1multiple interactionsISOEsr1 (Mus musculus)6480464CTD[Lipopolysaccharides co-treated with formononetin] results in increased expression of ESR1 proteinPMID:37269934
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