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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736559
Species: Homo sapiens
RGD Object: Gene
Symbol: ESR1
Name: estrogen receptor 1
Acc ID: CHEBI:17026
Term: progesterone
Definition: A C21-steroid hormone in which a pregnane skeleton carries oxo substituents at positions 3 and 20 and is unsaturated at C(4)-C(5). As a hormone, it is involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species.
Chemical ID: MESH:D011374
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ESR1decreases activityEXP 6480464CTDProgesterone results in decreased activity of ESR1 proteinPMID:25012808
ESR1decreases expressionEXP 6480464CTDProgesterone results in decreased expression of ESR1 mRNAPMID:18037150
ESR1increases activityEXP 6480464CTDProgesterone results in increased activity of ESR1 proteinPMID:22562034 PMID:25012808
ESR1multiple interactionsEXP 6480464CTDESR1 protein affects the reaction [Progesterone results in increased expression of GREB1 mRNA]; ESR1 protein affects the reaction [Progesterone results in increased expression of SGK1 mRNA]; Fulvestrant inhibits the reaction [Progesterone results in increased activity of ESR1 protein]PMID:22562034 PMID:33405908
ESR1decreases expressionISOEsr1 (Rattus norvegicus)6480464CTDProgesterone results in decreased expression of ESR1 mRNA; Progesterone results in decreased expression of ESR1 mRNA alternative form; Progesterone results in decreased expression of ESR1 proteinPMID:16002535 PMID:19094096
ESR1multiple interactionsISOEsr1 (Mus musculus)6480464CTDESR1 protein promotes the reaction [[Estradiol co-treated with Progesterone] results in increased expression of IHH mRNA]; ESR1 protein promotes the reaction [[Estradiol co-treated with Progesterone] results in increased expression of LIF mRNA]; Progesterone inhibits the reaction [ESR1 protein promotes the reaction [Estradiol results in increased expression of LPL mRNA]]PMID:17974624 PMID:25210133
ESR1multiple interactionsISOEsr1 (Rattus norvegicus)6480464CTD[Estradiol co-treated with Progesterone] results in decreased expression of ESR1 mRNA; [Estradiol co-treated with Progesterone] results in decreased expression of ESR1 mRNA alternative form; [Estradiol co-treated with Progesterone] results in increased expression of ESR1 mRNA; bisphenol A inhibits the reaction [[Estradiol co-treated with Progesterone] results in increased expression of ESR1 protein]; Diethylstilbestrol inhibits the reaction [[Estradiol co-treated with Progesterone] results in increased expression of ESR1 protein]; Progesterone inhibits the reaction [Estradiol results in increased expression of ESR1 mRNA]PMID:16002535 PMID:18653720 PMID:19094096 PMID:21277368
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