GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | ESR1 | affects binding | EXP | | 6480464 | CTD | DDT binds to ESR1 protein | PMID:12676605 PMID:19913605 | ESR1 | decreases expression | EXP | | 6480464 | CTD | DDT results in decreased expression of ESR1 mRNA | PMID:33728745 | ESR1 | increases activity | EXP | | 6480464 | CTD | DDT results in increased activity of ESR1 protein | PMID:11485867 PMID:15064155 PMID:18801367 PMID:22403704 PMID:26022396 PMID:26139245 PMID:26812056 | ESR1 | increases expression | EXP | | 6480464 | CTD | DDT results in increased expression of ESR1 mRNA | PMID:21295777 PMID:25014179 | ESR1 | multiple interactions | EXP | | 6480464 | CTD | [DDT analog co-treated with Hexachlorocyclohexane analog co-treated with Chlorobenzenes co-treated with Mirex co-treated with Polychlorinated Biphenyls co-treated with Chlordan co-treated with Toxaphene co-treated with Aldrin co-treated with Dieldrin] results in increased expression of ESR1 mRNA; [DDT results in increased activity of ESR1 protein] which results in decreased expression of GABRP mRNA; [DDT results in increased activity of ESR1 protein] which results in decreased expression of GSN mRNA; [DDT results in increased activity of ESR1 protein] which results in increased expression of BCL2 mRNA; [DDT results in increased activity of ESR1 protein] which results in increased expression of CTSD mRNA; [DDT results in increased activity of ESR1 protein] which results in increased expression of PGR mRNA; [DDT results in increased activity of ESR1 protein] which results in increased expression of SERPINB5 mRNA; [DDT results in increased activity of ESR1 protein] which results in increased expression of TFF1 mRNA; [Hexachlorocyclohexane co-treated with DDT] results in increased expression of ESR1; DDT binds to and results in increased activity of ESR1 protein | PMID:12676605 PMID:15026083 PMID:16329587 PMID:16626760 PMID:21295777 PMID:22403704 PMID:33049310 | ESR1 | affects binding | ISO | Esr1 (Mus musculus) | 6480464 | CTD | DDT binds to ESR1 protein | PMID:19913605 | ESR1 | decreases expression | ISO | Esr1 (Mus musculus) | 6480464 | CTD | DDT results in decreased expression of ESR1 protein | PMID:28263910 | ESR1 | increases activity | ISO | Esr1 (Rattus norvegicus) | 6480464 | CTD | DDT results in increased activity of ESR1 protein | PMID:9860891 | ESR1 | increases expression | ISO | Esr1 (Mus musculus) | 6480464 | CTD | DDT results in increased expression of ESR1 mRNA; DDT results in increased expression of ESR1 protein | PMID:15541753 PMID:28263910 | ESR1 | increases expression | ISO | Esr1 (Rattus norvegicus) | 6480464 | CTD | DDT results in increased expression of ESR1 mRNA | PMID:29477483 | ESR1 | increases methylation | ISO | Esr1 (Mus musculus) | 6480464 | CTD | DDT results in increased methylation of ESR1 gene | PMID:28263910 | ESR1 | multiple interactions | ISO | Esr1 (Mus musculus) | 6480464 | CTD | DDT promotes the reaction [ESR1 protein binds to CCND1 promoter]; DDT promotes the reaction [ESR1 protein binds to CDKN1A promoter] | PMID:23684557 | ESR1 | multiple interactions | ISO | Esr1 (Rattus norvegicus) | 6480464 | CTD | [o,p'-DDT co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Methoxychlor co-treated with Endosulfan co-treated with DDT] results in increased activity of ESR1 protein | PMID:9860891 | | ||||||||||||||||||||||
| Go Back to source page | Continue to Ontology report |