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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736559
Species: Homo sapiens
RGD Object: Gene
Symbol: ESR1
Name: estrogen receptor 1
Acc ID: CHEBI:1367
Term: 3,3',4,4'-tetrachlorobiphenyl
Definition: A tetrachlorobiphenyl that is biphenyl in which the hydrogens at position 3 and 4 on each phenyl group are replaced by chlorines.
Chemical ID: MESH:C028451
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ESR1affects bindingEXP 6480464CTD3,4,3',4'-tetrachlorobiphenyl binds to ESR1 proteinPMID:16293362
ESR1increases expressionEXP 6480464CTD3,4,3',4'-tetrachlorobiphenyl results in increased expression of ESR1 mRNAPMID:26519613
ESR1multiple interactionsEXP 6480464CTD3,4,3',4'-tetrachlorobiphenyl binds to and results in increased activity of ESR1 protein; 3,4,3',4'-tetrachlorobiphenyl promotes the reaction [ESR1 protein binds to CYP1A1 promoter]; 3,4,3',4'-tetrachlorobiphenyl promotes the reaction [ESR1 protein binds to KDM4B intron]; 3,4,3',4'-tetrachlorobiphenyl promotes the reaction [ESR1 protein binds to RELA promoter]; 3,4,3',4'-tetrachlorobiphenyl promotes the reaction [ESR1 protein binds to TFF1 promoter]; ESR1 protein promotes the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of KDM4B mRNA]PMID:16972788 PMID:26519613
ESR1multiple interactionsISOEsr1 (Mus musculus)6480464CTD3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of ESR1 mRNA]PMID:19467301
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