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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736485
Species: Mus musculus
RGD Object: Gene
Symbol: Sqstm1
Name: sequestosome 1
Acc ID: CHEBI:49900
Term: arsenous acid
Definition: An arsenic oxoacid consisting of three hydroxy groups attached to a central arsenic atom.
Chemical ID: MESH:C032793
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sqstm1affects expressionEXP 6480464CTDArsenic Trioxide affects the expression of SQSTM1 proteinPMID:33462182
Sqstm1decreases expressionEXP 6480464CTDArsenic Trioxide results in decreased expression of SQSTM1 proteinPMID:29111283 PMID:30237538 PMID:30677399 PMID:31846860 PMID:33462182
Sqstm1increases expressionEXP 6480464CTDArsenic Trioxide results in increased expression of SQSTM1 mRNA; Arsenic Trioxide results in increased expression of SQSTM1 proteinPMID:24801902 PMID:30225639 PMID:31846860 PMID:32112876 PMID:32781346
Sqstm1multiple interactionsEXP 6480464CTD3-methyladenine inhibits the reaction [Arsenic Trioxide results in decreased expression of SQSTM1 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in decreased expression of SQSTM1 protein]; Arsenic Trioxide affects the reaction [lipopolysaccharide, E coli O55-B5 affects the expression of SQSTM1 protein]; Chloroquine inhibits the reaction [Arsenic Trioxide results in decreased expression of SQSTM1 protein]; Taurine inhibits the reaction [Arsenic Trioxide results in decreased expression of SQSTM1 protein]; TFEB protein affects the reaction [Arsenic Trioxide results in decreased expression of SQSTM1 protein]PMID:30237538 PMID:30677399 PMID:33462182
Sqstm1affects bindingISOSQSTM1 (Homo sapiens)6480464CTDArsenic Trioxide binds to SQSTM1 proteinPMID:30237564
Sqstm1affects expressionISOSQSTM1 (Homo sapiens)6480464CTDArsenic Trioxide affects the expression of SQSTM1 proteinPMID:33462182
Sqstm1decreases expressionISOSqstm1 (Rattus norvegicus)6480464CTDArsenic Trioxide results in decreased expression of SQSTM1 proteinPMID:29111283
Sqstm1decreases expressionISOSQSTM1 (Homo sapiens)6480464CTDArsenic Trioxide results in decreased expression of SQSTM1 proteinPMID:29307831 PMID:30237538 PMID:30362509 PMID:30677399
Sqstm1decreases response to substanceISOSQSTM1 (Homo sapiens)6480464CTDSQSTM1 protein results in decreased susceptibility to Arsenic TrioxidePMID:20707922
Sqstm1increases expressionISOSqstm1 (Rattus norvegicus)6480464CTDArsenic Trioxide results in increased expression of SQSTM1 proteinPMID:30551535 PMID:31734849 PMID:35195477
Sqstm1increases expressionISOSQSTM1 (Homo sapiens)6480464CTDArsenic Trioxide results in increased expression of SQSTM1 mRNA; Arsenic Trioxide results in increased expression of SQSTM1 proteinPMID:20200477 PMID:21594580 PMID:27829220 PMID:30338810 PMID:31734849
Sqstm1multiple interactionsISOSqstm1 (Rattus norvegicus)6480464CTDferrostatin-1 inhibits the reaction [Arsenic Trioxide results in increased expression of SQSTM1 protein]; MAP1LC3B protein affects the reaction [Arsenic Trioxide results in decreased expression of SQSTM1 protein]; Taurine inhibits the reaction [Arsenic Trioxide results in increased expression of SQSTM1 protein]PMID:29111283 PMID:30551535 PMID:35195477
Sqstm1multiple interactionsISOSQSTM1 (Homo sapiens)6480464CTD3-methyladenine inhibits the reaction [Arsenic Trioxide results in decreased expression of SQSTM1 protein]; [Tretinoin co-treated with Arsenic Trioxide] results in increased expression of SQSTM1 mRNA; Arsenic Trioxide promotes the reaction [EGFR protein mutant form binds to SQSTM1 protein]; Arsenic Trioxide promotes the reaction [SQSTM1 protein binds to FLT3 protein mutant form]; Arsenic Trioxide promotes the reaction [SQSTM1 protein results in increased localization of BCR protein mutant form]; Chloroquine inhibits the reaction [Arsenic Trioxide results in decreased expression of SQSTM1 protein]; Chloroquine promotes the reaction [Arsenic Trioxide results in increased expression of SQSTM1 protein]; Palmitic Acid inhibits the reaction [Arsenic Trioxide results in decreased expression of SQSTM1 protein]; Rosiglitazone inhibits the reaction [Arsenic Trioxide results in decreased expression of SQSTM1 protein]; SQSTM1 protein affects the reaction [Arsenic Trioxide results in decreased expression of EGFR protein]; SQSTM1 protein inhibits the reaction [Arsenic Trioxide results in decreased expression of EGFR protein]; SQSTM1 protein promotes the reaction [Arsenic Trioxide results in increased degradation of BCR protein mutant form]; Taurine inhibits the reaction [Arsenic Trioxide results in decreased expression of SQSTM1 protein]PMID:15894607 PMID:22898604 PMID:29307831 PMID:30237538 PMID:30237564 PMID:30338810 PMID:30362509 PMID:30677399 PMID:32284743
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