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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736485
Species: Mus musculus
RGD Object: Gene
Symbol: Sqstm1
Name: sequestosome 1
Acc ID: CHEBI:18721
Term: 3-chloropropane-1,2-diol
Definition: A chloropropane-1,2-diol that is propane-1,2-diol substituted by a chloro group at position 3.
Chemical ID: MESH:D000517
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sqstm1increases expressionISOSqstm1 (Rattus norvegicus)6480464CTDalpha-Chlorohydrin results in increased expression of SQSTM1 proteinPMID:33187795
Sqstm1increases expressionISOSQSTM1 (Homo sapiens)6480464CTDalpha-Chlorohydrin results in increased expression of SQSTM1 proteinPMID:32702505 PMID:34812491
Sqstm1multiple interactionsISOSqstm1 (Rattus norvegicus)6480464CTDalpha-Chlorohydrin promotes the reaction [glycidol results in increased expression of SQSTM1 protein]; glycidol promotes the reaction [alpha-Chlorohydrin results in increased expression of SQSTM1 protein]PMID:33187795
Sqstm1multiple interactionsISOSQSTM1 (Homo sapiens)6480464CTD3-methyladenine promotes the reaction [alpha-Chlorohydrin results in increased expression of SQSTM1 protein]; Chloroquine promotes the reaction [alpha-Chlorohydrin results in increased expression of SQSTM1 protein]; ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in increased expression of SQSTM1 protein]; TFEB protein inhibits the reaction [alpha-Chlorohydrin results in increased expression of SQSTM1 protein]PMID:32702505 PMID:34812491
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