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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736485
Species: Mus musculus
RGD Object: Gene
Symbol: Sqstm1
Name: sequestosome 1
Acc ID: CHEBI:15756
Term: hexadecanoic acid
Definition: A straight-chain, sixteen-carbon, saturated long-chain fatty acid.
Chemical ID: MESH:D019308
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sqstm1increases expressionEXP 6480464CTDPalmitic Acid results in increased expression of SQSTM1 proteinPMID:30208301
Sqstm1multiple interactionsEXP 6480464CTDtrigonelline inhibits the reaction [Palmitic Acid results in increased expression of SQSTM1 protein]PMID:30208301
Sqstm1increases expressionISOSqstm1 (Rattus norvegicus)6480464CTDPalmitic Acid results in increased expression of SQSTM1 proteinPMID:32278738 PMID:34774660
Sqstm1increases expressionISOSQSTM1 (Homo sapiens)6480464CTDPalmitic Acid results in increased expression of SQSTM1 proteinPMID:30208301 PMID:32283200
Sqstm1multiple interactionsISOSqstm1 (Rattus norvegicus)6480464CTDCYLD protein affects the reaction [Palmitic Acid results in increased expression of SQSTM1 protein]; PKF115-584 inhibits the reaction [CYLD protein affects the reaction [Palmitic Acid results in increased expression of SQSTM1 protein]]; SQSTM1 protein affects the reaction [Palmitic Acid affects the localization of AIFM1 protein]; SQSTM1 protein affects the reaction [Palmitic Acid results in increased cleavage of CASP3 protein]PMID:34774660
Sqstm1multiple interactionsISOSQSTM1 (Homo sapiens)6480464CTD[Palmitic Acid co-treated with Oleic Acid] results in increased expression of SQSTM1 protein; Deferoxamine promotes the reaction [Palmitic Acid results in increased expression of SQSTM1 protein]; Escin inhibits the reaction [[Palmitic Acid co-treated with Oleic Acid] results in increased expression of SQSTM1 protein]; Palmitic Acid inhibits the reaction [Arsenic Trioxide results in decreased expression of SQSTM1 protein]; trigonelline inhibits the reaction [Palmitic Acid results in increased expression of SQSTM1 protein]PMID:30208301 PMID:30362509 PMID:32283200 PMID:36905866
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