GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Sqstm1 | decreases expression | ISO | SQSTM1 (Homo sapiens) | 6480464 | CTD | Acrolein results in decreased expression of SQSTM1 protein | PMID:29902662 PMID:30205151 PMID:34238121 | Sqstm1 | increases expression | ISO | Sqstm1 (Rattus norvegicus) | 6480464 | CTD | Acrolein results in increased expression of SQSTM1 protein | PMID:35150775 | Sqstm1 | increases expression | ISO | SQSTM1 (Homo sapiens) | 6480464 | CTD | Acrolein results in increased expression of SQSTM1 mRNA | PMID:24211530 | Sqstm1 | multiple interactions | ISO | SQSTM1 (Homo sapiens) | 6480464 | CTD | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased expression of SQSTM1 mRNA; [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased expression of SQSTM1 mRNA; Acetylcysteine inhibits the reaction [Acrolein results in decreased expression of SQSTM1 protein] | PMID:30205151 PMID:32699268 | |
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