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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736474
Species: Homo sapiens
RGD Object: Gene
Symbol: G6PD
Name: glucose-6-phosphate dehydrogenase
Acc ID: CHEBI:9288
Term: streptozocin
Definition: An N-nitrosourea that is an antibiotic produced by Streptomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.
Chemical ID: MESH:D013311
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
G6PDdecreases activityISOG6pd (Rattus norvegicus)6480464CTDStreptozocin results in decreased activity of G6PD proteinPMID:19133311 PMID:19682444 PMID:25641191 PMID:26944432 PMID:28330423 PMID:28757134 PMID:31345080
G6PDdecreases expressionISOG6pd (Rattus norvegicus)6480464CTDStreptozocin results in decreased expression of G6PD mRNA; Streptozocin results in decreased expression of G6PD proteinPMID:35478295
G6PDmultiple interactionsISOG6pdx (Mus musculus)6480464CTD[Streptozocin co-treated with Dietary Fats] results in decreased activity of G6PD protein; Diethylhexyl Phthalate promotes the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased activity of G6PD protein]PMID:33484791
G6PDmultiple interactionsISOG6pd (Rattus norvegicus)6480464CTD2-tert-butylhydroquinone inhibits the reaction [Streptozocin results in decreased expression of G6PD mRNA]; 2-tert-butylhydroquinone inhibits the reaction [Streptozocin results in decreased expression of G6PD protein]; 4-hydroxyphenylethanol inhibits the reaction [Streptozocin results in decreased activity of G6PD protein]; [Phytic Acid co-treated with Inositol] inhibits the reaction [Streptozocin results in decreased activity of G6PD protein]; [Streptozocin co-treated with Cadmium] results in decreased activity of G6PD protein; [Streptozocin co-treated with Niacinamide] affects the activity of G6PD protein; arjunolic acid inhibits the reaction [Streptozocin results in decreased activity of G6PD protein]; citronellol inhibits the reaction [Streptozocin results in decreased activity of G6PD protein]; G6PD protein promotes the reaction [Streptozocin results in decreased expression of NFE2L2 mRNA]; G6PD protein promotes the reaction [Streptozocin results in decreased expression of NFE2L2 protein]; geraniol inhibits the reaction [Streptozocin results in decreased activity of G6PD protein]; Gliclazide inhibits the reaction [Streptozocin results in decreased activity of G6PD protein]; Glyburide inhibits the reaction [Streptozocin results in decreased activity of G6PD protein]; Hesperidin inhibits the reaction [Streptozocin results in decreased activity of G6PD protein]; myricetin inhibits the reaction [[Streptozocin co-treated with Cadmium] results in decreased activity of G6PD protein]; NFE2L2 protein inhibits the reaction [Streptozocin results in decreased expression of G6PD mRNA]; NFE2L2 protein inhibits the reaction [Streptozocin results in decreased expression of G6PD protein]; Resveratrol inhibits the reaction [[Streptozocin co-treated with Niacinamide] affects the activity of G6PD protein]PMID:19059388 PMID:19133311 PMID:19682444 PMID:24923654 PMID:25641191 PMID:26944432 PMID:28330423 PMID:28757134 PMID:31345080 PMID:35478295
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