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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735760
Species: Homo sapiens
RGD Object: Gene
Symbol: ATF3
Name: activating transcription factor 3
Acc ID: CHEBI:90705
Term: SB 203580
Definition: A member of the class of imidazoles carrying 4-methylsulfinylphenyl, 4-pyridyl and 4-fluorophenyl substituents at positions 2, 4 and 5 respectively. An inhibitor of mitogen-activated protein kinase.
Chemical ID: MESH:C093642
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ATF3multiple interactionsEXP 6480464CTDSB 203580 inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of ATF3 protein]; SB 203580 inhibits the reaction [Clotrimazole results in increased expression of ATF3 mRNA]; SB 203580 inhibits the reaction [deoxynivalenol results in decreased degradation of ATF3 mRNA]; SB 203580 inhibits the reaction [deoxynivalenol results in decreased degradation of ATF3 protein]PMID:19101521 PMID:27507784 PMID:33921748
ATF3multiple interactionsISOAtf3 (Mus musculus)6480464CTDSB 203580 inhibits the reaction [Acrylamide results in increased expression of ATF3 protein]PMID:25531190
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