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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735760
Species: Homo sapiens
RGD Object: Gene
Symbol: ATF3
Name: activating transcription factor 3
Acc ID: CHEBI:45863
Term: paclitaxel
Definition: A tetracyclic diterpenoid isolated originally from the bark of the Pacific yew tree, Taxus brevifolia. It is a mitotic inhibitor used in cancer chemotherapy. Note that the use of the former generic name 'taxol' is now limited, as Taxol is a registered trade mark.
Chemical ID: MESH:D017239
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ATF3affects response to substanceEXP 6480464CTD[ATF3 protein affects the susceptibility to Arsenic] which affects the susceptibility to Paclitaxel; ATF3 protein affects the susceptibility to PaclitaxelPMID:34364923
ATF3increases expressionISOAtf3 (Rattus norvegicus)6480464CTDPaclitaxel results in increased expression of ATF3 proteinPMID:16854522 PMID:17005179 PMID:17686523 PMID:18754875 PMID:21050491 PMID:35662665
ATF3multiple interactionsISOAtf3 (Rattus norvegicus)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Trimetazidine inhibits the reaction [Paclitaxel results in increased expression of ATF3 protein]]; Minocycline inhibits the reaction [Paclitaxel results in increased expression of ATF3 protein]; Trimetazidine inhibits the reaction [Paclitaxel results in increased expression of ATF3 protein]PMID:21050491 PMID:35662665
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