GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | ATF3 | decreases degradation | EXP | | 6480464 | CTD | deoxynivalenol results in decreased degradation of ATF3 mRNA; deoxynivalenol results in decreased degradation of ATF3 protein | PMID:19101521 | ATF3 | increases expression | EXP | | 6480464 | CTD | deoxynivalenol results in increased expression of ATF3 mRNA; deoxynivalenol results in increased expression of ATF3 protein; deoxynivalenol results in increased expression of ATF3 protein alternative form | PMID:19101521 PMID:19360757 PMID:22003189 PMID:22846391 PMID:30286430 PMID:35314294 | ATF3 | increases response to substance | EXP | | 6480464 | CTD | ATF3 protein results in increased susceptibility to deoxynivalenol | PMID:19101521 | ATF3 | multiple interactions | EXP | | 6480464 | CTD | [[[Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] which affects the localization of ELAVL1 protein] which co-treated with deoxynivalenol] promotes the reaction [[ELAVL1 protein binds to ATF3 3' UTR] which results in increased stability of ATF3 mRNA]; [[Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] which co-treated with deoxynivalenol] results in increased stability of ATF3 mRNA; [Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] promotes the reaction [deoxynivalenol results in increased expression of ATF3 mRNA]; ATF3 protein affects the reaction [[[Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] which co-treated with deoxynivalenol] affects the phosphorylation of RELA protein]; ATF3 protein affects the reaction [deoxynivalenol results in increased expression of EGR1 protein]; EP300 protein affects the reaction [deoxynivalenol results in increased expression of ATF3 protein alternative form]; KAT2A protein affects the reaction [deoxynivalenol results in increased expression of ATF3 protein alternative form]; KAT2B protein affects the reaction [deoxynivalenol results in increased expression of ATF3 protein alternative form]; N-(4-methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea inhibits the reaction [deoxynivalenol results in decreased degradation of ATF3 protein]; SB 203580 inhibits the reaction [deoxynivalenol results in decreased degradation of ATF3 mRNA]; SB 203580 inhibits the reaction [deoxynivalenol results in decreased degradation of ATF3 protein] | PMID:19101521 PMID:22003189 PMID:30286430 | ATF3 | decreases expression | ISO | Atf3 (Mus musculus) | 6480464 | CTD | deoxynivalenol results in decreased expression of ATF3 mRNA | PMID:23253260 | ATF3 | increases expression | ISO | Atf3 (Mus musculus) | 6480464 | CTD | deoxynivalenol results in increased expression of ATF3 mRNA | PMID:21074547 | | ||||||||||||||||||||||
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