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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735591
Species: Homo sapiens
RGD Object: Gene
Symbol: IL10
Name: interleukin 10
Acc ID: CHEBI:17688
Term: (S)-nicotine
Definition: A 3-(1-methylpyrrolidin-2-yl)pyridine in which the chiral centre has S-configuration. The naturally occurring and most active enantiomer of nicotine, isolated from Nicotiana tabacum.
Chemical ID: MESH:D009538
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
IL10decreases expressionEXP 6480464CTDNicotine results in decreased expression of IL10 mRNAPMID:18247414
IL10multiple interactionsEXP 6480464CTDNicotine inhibits the reaction [Lipopolysaccharides results in increased secretion of IL10 protein]PMID:29673796
IL10decreases expressionISOIl10 (Mus musculus)6480464CTDNicotine results in decreased expression of IL10 mRNAPMID:21237301
IL10decreases secretionISOIl10 (Mus musculus)6480464CTDNicotine results in decreased secretion of IL10 proteinPMID:21237301
IL10multiple interactionsISOIl10 (Mus musculus)6480464CTD[Eugenol co-treated with Acetylcysteine] inhibits the reaction [Nicotine results in decreased secretion of IL10 protein]; Acetylcysteine inhibits the reaction [Nicotine results in decreased expression of IL10 mRNA]; Eugenol inhibits the reaction [Nicotine results in decreased expression of IL10 mRNA]; Nicotine inhibits the reaction [Dextran Sulfate results in decreased expression of IL10 protein]PMID:21237301 PMID:31926917
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