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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735259
Species: Homo sapiens
RGD Object: Gene
Symbol: ACADM
Name: acyl-CoA dehydrogenase medium chain
Acc ID: CHEBI:35549
Term: perfluorooctanoic acid
Definition: A fluoroalkanoic acid that is perfluorinated octanoic acid.
Chemical ID: MESH:C023036
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ACADMincreases expressionEXP 6480464CTDperfluorooctanoic acid results in increased expression of ACADM mRNA; perfluorooctanoic acid results in increased expression of ACADM proteinPMID:26879310 PMID:32068100 PMID:37302725
ACADMmultiple interactionsEXP 6480464CTD[PPARA co-treated with perfluorooctanoic acid] results in increased expression of ACADM mRNA; [PPARA co-treated with perfluorooctanoic acid] results in increased expression of ACADM proteinPMID:19751795
ACADMaffects expressionISOAcadm (Mus musculus)6480464CTDperfluorooctanoic acid affects the expression of ACADM mRNAPMID:19429403
ACADMincreases expressionISOAcadm (Mus musculus)6480464CTDperfluorooctanoic acid results in increased expression of ACADM mRNA; perfluorooctanoic acid results in increased expression of ACADM proteinPMID:17681415 PMID:21499893 PMID:23626681 PMID:34252412
ACADMincreases expressionISOAcadm (Rattus norvegicus)6480464CTDperfluorooctanoic acid results in increased expression of ACADM mRNAPMID:16221955
ACADMmultiple interactionsISOAcadm (Mus musculus)6480464CTD[perfluorooctanoic acid co-treated with Dietary Fats, Unsaturated] results in increased expression of ACADM mRNAPMID:23626681
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