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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735043
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Myd88
Name: MYD88, innate immune signal transduction adaptor
Acc ID: CHEBI:28001
Term: vancomycin
Definition: A complex glycopeptide from Streptomyces orientalis. It inhibits a specific step in the synthesis of the peptidoglycan layer in the Gram-positive bacteria Staphylococcus aureus and Clostridium difficile.
Chemical ID: MESH:D014640
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Myd88decreases expressionISOMyd88 (Mus musculus)6480464CTDVancomycin results in decreased expression of MYD88 mRNAPMID:18930951
Myd88multiple interactionsISOMyd88 (Mus musculus)6480464CTD[Gentamicins co-treated with Vancomycin co-treated with Cefoxitin co-treated with Metronidazole] inhibits the reaction [Fluorides results in increased expression of MYD88 mRNA]; [Neomycin co-treated with Metronidazole co-treated with Ampicillin co-treated with Vancomycin] inhibits the reaction [Methamphetamine results in increased expression of MYD88 mRNA]; [Neomycin co-treated with Metronidazole co-treated with Ampicillin co-treated with Vancomycin] inhibits the reaction [Methamphetamine results in increased expression of MYD88 protein]PMID:35390362 PMID:37269894
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