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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733442
Species: Mus musculus
RGD Object: Gene
Symbol: Eif4ebp1
Name: eukaryotic translation initiation factor 4E binding protein 1
Acc ID: CHEBI:37537
Term: phorbol 13-acetate 12-myristate
Definition: A phorbol ester that is phorbol in which the hydroxy groups at the cyclopropane ring juction (position 13) and the adjacent carbon (position 12) have been converted into the corresponding acetate and myristate esters. It is a major active constituent of the seed oil of Croton tiglium. It has been used as a tumour promoting agent for skin carcinogenesis in rodents and is associated with increased cell proliferation of malignant cells. However its function is controversial since a decrease in cell proliferation has also been observed in several cancer cell types.
Chemical ID: MESH:D013755
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Eif4ebp1increases phosphorylationISOEIF4EBP1 (Homo sapiens)6480464CTDTetradecanoylphorbol Acetate results in increased phosphorylation of EIF4EBP1 proteinPMID:12781867
Eif4ebp1multiple interactionsISOEIF4EBP1 (Homo sapiens)6480464CTDTetradecanoylphorbol Acetate inhibits the reaction [EIF4EBP1 protein binds to EIF4E protein]PMID:12781867
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