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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733364
Species: Homo sapiens
RGD Object: Gene
Symbol: NR1H3
Name: nuclear receptor subfamily 1 group H member 3
Acc ID: CHEBI:42977
Term: 25-hydroxycholesterol
Definition: A 25-hydroxy steroid that has formula 402.65294.
Chemical ID: MESH:C007997
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NR1H3increases activityEXP 6480464CTD25-hydroxycholesterol results in increased activity of NR1H3 proteinPMID:27052460
NR1H3multiple interactionsEXP 6480464CTD[25-hydroxycholesterol binds to and results in increased activity of NR1H3 protein] which results in increased expression of ABCA1 mRNA; [25-hydroxycholesterol binds to and results in increased activity of NR1H3 protein] which results in increased transport of Cholesterol; [9-deoxy-delta-9-prostaglandin D2 binds to and results in increased activity of PPARG protein] promotes the reaction [[25-hydroxycholesterol binds to and results in increased activity of NR1H3 protein] which results in increased expression of ABCA1 mRNA]; [9-deoxy-delta-9-prostaglandin D2 binds to and results in increased activity of PPARG protein] promotes the reaction [[25-hydroxycholesterol binds to and results in increased activity of NR1H3 protein] which results in increased transport of Cholesterol]; [Bezafibrate binds to and results in increased activity of PPARA protein] promotes the reaction [[25-hydroxycholesterol binds to and results in increased activity of NR1H3 protein] which results in increased expression of ABCA1 mRNA]; [Bezafibrate binds to and results in increased activity of PPARA protein] promotes the reaction [[25-hydroxycholesterol binds to and results in increased activity of NR1H3 protein] which results in increased transport of Cholesterol]; SULT2B1 protein inhibits the reaction [25-hydroxycholesterol results in increased activity of NR1H3 protein]PMID:12595494 PMID:27052460
NR1H3increases activityISONr1h3 (Mus musculus)6480464CTD25-hydroxycholesterol results in increased activity of NR1H3 proteinPMID:9603267
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